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《医学前沿（英文）》 2018年 第12卷 第3期 页码 307-318 doi: 10.1007/s11684-017-0547-2
Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of extract (GBE) against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel rat cortical capillary endothelial cell-astrocyte-neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B (GB), against oxygen–glucose deprivation/reoxygenation and glucose (OGD/R) injury. In this model, rat cortical capillary endothelial cells, astrocytes, and neurons were cocultured so that they could be synchronously observed in the same system. Pretreatment with GBE or GB increased the neuron cell viability, ameliorated cell injury, and inhibited the cell apoptotic rate through Bax and Bcl-2 expression regulation after OGD/R injury. Furthermore, GBE or GB pretreatment enhanced the transendothelial electrical resistance of capillary endothelial monolayers, reduced the endothelial permeability coefficients for sodium fluorescein (Na-F), and increased the expression levels of tight junction proteins, namely, ZO-1 and occludin, in endothelial cells. Results demonstrated the preventive effects of GBE on neuronal cell death and enhancement of the function of brain capillary endothelial monolayers after OGD/R injury ; thus, GBE could be used as an effective neuroprotective agent for AIS/reperfusion, with GB as one of its significant constituents.
关键词： acute ischemic stroke Ginkgo bilobaextract Ginkgolide B network model neuroprotection
孟昭礼,方向阳,罗兰,尚坚
《中国工程科学》 2007年 第9卷 第3期 页码 28-34
银泰（1－对羟基苯基丁酮）是以银杏外种皮提纯物白果酚为先导化合物仿生合成的一种杀菌剂。其中，银杏果实乙醇粗提物8.3倍和25倍液对苹果腐烂病抑菌率达100％和50％；银杏果实外种皮提纯物白果酚200倍和400倍液对苹果腐烂病病菌抑菌率均为100％。20％银泰微乳剂对苹果腐烂病、番茄灰霉病等4种病菌 EC50 为17.26～48.43mg/L，分别优于对照药剂；田间防治小麦纹枯病等4种病害效果达85％以上；对非靶标生物安全，且不易产生抗药性。仿生合成的银泰原药对大白鼠毒性试验，经口、经皮 LD50 均为4640mg/kg，20％银泰乳油对大白鼠毒性试验，经口LD50为3160mg/kg，经皮 LD50 为2150mg/kg；亚慢性经口毒性（90d）试验雌为19.1mg/kg，雄为18.3mg/kg；Ames、细胞微核和染色体畸变试验均为阴性结果。
标题 作者 时间 类型 操作
Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/
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